Séquence des peptides endogènes :


- Peptides dérivés de la pro-opiomélanocortine (POMC) :

- adrénocorticotropine (ACTH) (39 aa)
- a-mélanotropine (a-MSH) (13 aa)
- b-mélanotropine (b-MSH) (22 aa)
- g-mélanotropine (g-MSH) (11 aa)
- b-lipotropine (b-LPH) (91 aa)
- g-lipotropine (g-LPH) (56 aa)
- b-endorphine (31 aa)
- Met-enképhaline (5 aa)

Adrénomédulline (52 aa) (pont disulfure : Cys¹⁶ - Cys²¹) :
Tyr - Arg - Gln - Ser - Met - Asn - Asn - Phe - Gln - Gly - Leu - Arg - Ser - Phe - Gly - Cys - Arg - Phe - Gly - Thr - Cys - Thr - Val - Gln - Lys - Leu - Ala - His - Gln - Ile - Tyr - Gln - Phe - Thr - Asp - Lys - Asp - Lys - Asp - Asn - Val - Ala - Pro - Arg - Ser - Lys - Ile - Ser - Pro - Gln - Gly - Tyr-NH₂


Amyline (37 aa) (pont disulfure : Cys² - Cys⁷) :
Lys - Cys - Asn - Thr - Ala - Thr - Cys - Ala - Thr - Gln - Arg - Leu - Ala - Asn - Phe - Leu - Val - His - Ser - Ser - Asn - Asn - Phe - Gly - Ala - Ile - Leu - Ser - Ser - Thr - Asn - Val - Gly - Ser - Asn - Thr - Tyr-NH₂


Angiotensine II (8 aa) :
Asp - Arg - Val - Tyr - Ile - His - Pro - Phe


Apéline (36 aa) :
Leu - Val - Gln - Pro - Arg - Gly - Ser - Arg - Asn - Gly - Pro - Gly - Pro - Trp - Gln - Gly - Gly - Arg - Arg - Lys - Phe - Arg - Arg - Gln - Arg - Pro - Arg - Leu - Ser - His - Lys - Gly - Pro - Met - Pro - Phe


Bradykinine (9 aa) :
Arg - Pro - Pro - Gly - Phe - Ser - Pro - Phe - Arg


Kallidine (Lysyl-bradykinine) (10 aa) :
Lys - Arg - Pro - Pro - Gly - Phe - Ser - Pro - Phe - Arg


Calcitonine (32 aa) (Pont disulfure : Cys¹ - Cys⁷) :
Cys - Gly - Asn - Leu - Ser - Thr - Cys - Met - Leu - Gly - Thr - Tyr - Thr - Gln - Asp - Phe - Asn - Lys - Phe - His - Thr - Phe - Pro - Gln - Thr - Ala - Ile - Gly - Val - Gly - Ala - Pro-NH₂


Calcitonin Gene Related Peptide I (CGRP a) (37 aa) (pont disulfure : Cys² - Cys⁷) :
Ala - Cys - Asp - Thr - Ala - Thr - Cys - Val - Thr - His - Arg - Leu - Ala - Gly - Leu - Leu - Ser - Arg - Ser - Gly - Gly - Val - Val - Lys - Asn - Asn - Phe - Val - Pro - Thr - Asn - Val - Gly - Ser - Lys - Ala - Phe-NH₂


- Calcitonin Gene Related Peptide II (CGRP b) (37 aa)


- Cholécystokinine (CCK) (58 aa, 8 aa)


CRF (Corticotropin-Releasing Factor) (41 aa) :
Ser - Glu - Glu - Pro - Pro - Ile - Ser - Leu - Asp - Leu - Thr - Phe - His - Leu - Leu - Arg - Glu - Val - Leu - Glu - Met - Ala - Arg - Ala - Glu - Gln - Leu - Ala - Gln - Gln - Ala - His - Ser - Asn - Arg - Lys - Leu - Met - Glu - Ile - Ile - NH2


Dynorphine A (17 aa) :
Tyr - Gly - Gly - Phe - Leu - Arg - Arg - Ile - Arg - Pro - Lys - Leu - Lys - Trp - Asp - Asn - Gln


Dyn A / Dynorphine B (13 aa) / a-Néo-endorphine (10 aa) / b-Néo-endorphine (9 aa)


Endomorphine 1 (4 aa) :
Tyr - Pro - Trp - Phe-NH₂


Endomorphine 2 (4 aa) :
Tyr - Pro - Phe - Phe-NH₂


Endotheline 1 (21 aa) (ponts disulfures : Cys¹ - Cys¹⁵ et Cys³ - Cys¹¹) :
Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp


Endotheline 2 (21 aa) (ponts disulfures : Cys¹ - Cys¹⁵ et Cys³ - Cys¹¹) :
Cys - Ser - Cys - Ser - Ser - Trp - Leu - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp


Endotheline 3 (21 aa) (ponts disulfures : Cys¹ - Cys¹⁵ et Cys³ - Cys¹¹) :
Cys - Thr - Cys - Phe - Thr - Tyr - Lys - Asp - Lys - Glu - Cys - Val - Tyr - Tyr - Cys - His - Leu - Asp - Ile - Ile - Trp


Leu-enképhaline (5 aa) :
Tyr - Gly - Gly - Phe - Leu


Met-enképhaline (5 aa) :
Tyr - Gly - Gly - Phe - Met


Galanine (30 aa) :
Gly - Trp - Thr - Leu - Asn - Ser - Ala - Gly - Tyr - Leu - Leu - Gly - Pro - His - Ala - Val - Gly - Asn - His - Arg - Ser - Phe - Ser - Asp - Lys - Asn - Gly - Leu - Thr - Ser


- Galanin mRNA associated peptide (GMAP) (30 aa)


Gastric-Inhibitory Peptide (Glucose-dependent insulinotropic polypeptide) (GIP) (42 aa) :
Tyr - Ala - Glu - Gly - Thr - Phe - Ile - Ser - Asp - Tyr - Ser - Ile - Ala - Met - Asp - Lys - Ile - His - Gln - Gln - Asp - Phe - Val - Asn - Trp - Leu - Leu - Ala - Gln - Lys - Gly - Lys - Lys - Asn - Asp - Trp - Lys - His - Asn - Ile - Thr - Gln


Gastrine (17 aa) :
NH₂-Glu - Gly - Pro - Trp - Leu - Glu - Glu - Glu - Glu - Glu - Ala - Tyr - Gly - Trp - Met - Asp - Phe-NH₂


- Gastrine (34 aa)


- Gastrin-Releasing Peptide (GRP) (27 aa)


Gastrin-Releasing Peptide 18-27 - GRP(18-27) (neuromédine C) (10 aa) :
Gly - Asn - His - Trp - Ala - Val - Gly - His - Leu - Met-NH₂


Ghréline (28 aa) :
Gly - Ser - Ser(n - Octanoyl) - Phe - Leu - Ser - Pro - Glu - His - Gln - Arg - Val - Gln - Gln - Arg - Lys - Glu - Ser - Lys - Lys - Pro - Pro - Ala - Lys - Leu - Gln - Pro - Arg


Growth Hormone-Releasing Hormone - GH-RH (Growth Hormone Releasing Factor - GRF) (44 aa) :
Tyr - Ala - Asp - Ala - Ile - Phe - Thr - Asn - Ser - Tyr - Arg - Lys - Val - Leu - Gly - Gln - Leu - Ser - Ala - Arg - Lys - Leu - Leu - Gln - Asp - Ile - Met - Ser - Arg - Gln - Gln - Gly - Glu - Ser - Asn - Gln - Glu - Arg - Gly - Ala - Arg - Ala - Arg - Leu-NH₂


Glucagon (29 aa) :
His - Ser - Gln - Gly - Thr - Phe - Thr - Ser - Asp - Tyr - Ser - Lys - Tyr - Leu - Asp - Ser - Arg - Arg - Ala - Gln - Asp - Phe - Val - Gln - Trp - Leu - Met - Asn - Thr


- Glucagon / Glicentine (69 aa) / Oxyntomoduline (37 aa)


Glucagon-like Peptide 1 (30 aa) :
His - Ala - Glu - Gly - Thr - Phe - Thr - Ser - Asp - Val - Ser - Ser - Tyr - Leu - Glu - Gly - Gln - Ala - Ala - Lys - Glu - Phe - Ile - Ala - Trp - Leu - Val - Lys - Gly - Arg - Gly


Glucagon - like Peptide 2 (GLP-2) (33 aa) :
His - Ala - Asp - Gly - Ser - Phe - Ser - Asp - Glu - Met - Asn - Thr - Ile - Leu - Asp - Asn - Leu - Ala - Ala - Arg - Asp - Phe - Ile - Asn - Trp - Leu - Ile - Gln - Thr - Lys - Ile - Thr - Asp


- Gonadotropin Releasing hormone (GnRH) (10 aa) / Prolactin release-inhibiting factor (PIF)


Melanin-concentrating hormone (MCH) (19 aa) (pont disulfure : Cys⁷ - Cys¹⁶) :
Asp - Phe - Asp - Met - Leu - Arg - Cys - Met - Leu - Gly - Arg - Val - Tyr - Arg - Pro - Cys - Trp - Gln - Val


Motiline (22 aa) :
Phe - Val - Pro - Ile - Phe - Thr - Tyr - Gly - Glu - Leu - Gln - Arg - Met - Gln - Glu - Lys - Glu - Arg - Asn - Lys - Gly - Gln


Neurokinine B (neuromédine K) (10 aa) :
Asp - Met - His - Asp - Phe - Phe - Val - Gly - Leu - Met-NH₂


- Neuropeptide FF (NPFF)


- Neuropeptide AF (NPAF)


Neuropeptide Y (36 aa) :
Tyr - Pro - Ser - Lys - Pro - Asp - Asn - Pro - Gly - Glu - Asp - Ala - Pro - Ala - Glu - Asp - Met - Ala - Arg - Tyr - Tyr - Ser - Ala - Leu - Arg - His - Tyr - Ile - Asn - Leu - Ile - Thr - Arg - Gln - Arg - Tyr-NH₂


Neuropeptide YY (36 aa) :
Tyr - Pro - Ile - Lys - Pro - Glu - Ala - Pro - Gly - Glu - Asp - Ala - Ser - Pro - Glu - Glu - Leu - Asn - Arg - Tyr - Tyr - Ala - Ser - Leu - Arg - His - Tyr - Leu - Asn - Leu - Val - Thr - Arg - Gln - Arg - Tyr-NH₂


Neurotensine (13 aa) :
pyroGlu - Leu - Tyr - Glu - Asn - Lys - Pro - Arg - Arg - Pro - Tyr - Ile - Leu


Neuromédine N (6 aa) :
Lys - Ile - Pro - Tyr - Ile - Leu


Neuromédine B (10 aa) :
Gly - Asn - Leu - Trp - Ala - Thr - Gly - His - Phe - Met-NH₂


- Neuromédine U (25 aa)


Nociceptine (orphanine FQ) (17 aa) :
Phe - Gly - Gly - Phe - Thr - Gly - Ala - Arg - Lys - Ser - Ala - Arg - Lys - Leu - Ala - Asn - Gln


Ocytocine (9 aa) (pont disulfure : Cys¹ - Cys⁶) :
Cys - Tyr - Ile - Gln - Asn - Cys - Pro - Leu - Gly-NH₂


Oréxine A (34 aa) (ponts disulfures : Cys⁶ - Cys¹² et Cys⁷ - Cys¹⁴) :
Pyr - Pro - Leu - Pro - Asp - Cys - Cys - Arg - Gln - Lys - Thr - Cys - Ser - Cys - Arg - Leu - Tyr - Glu - Leu - Leu - His - Gly - Ala - Gly - Asn - His - Ala - Ala - Gly - Ile - Leu - Thr - Leu-NH₂


Oréxine B (28 aa) :
Arg - Ser - Gly - Pro - Pro - Gly - Leu - Gln - Gly - Arg - Leu - Gln - Arg - Leu - Leu - Gln - Ala - Ser - Gly - Asn - His - Ala - Ala - Gly - Ile - Leu - Thr - Met-NH₂


PACAP-27 (Pituitary Adenylyl Cyclase-Activating Peptide) (27 aa) :
His - Ser - Asp - Gly - Ile - Phe - Thr - Asp - Ser - Tyr - Ser - Arg - Tyr - Arg - Lys - Gln - Met - Ala - Val - Lys - Lys - Tyr - Leu - Ala - Ala - Val - Leu-NH₂


PACAP-38 (Pituitary Adenylyl Cyclase-Activating Peptide) (38 aa) :
His - Ser - Asp - Gly - Ile - Phe - Thr - Asp - Ser - Tyr - Ser - Arg - Tyr - Arg - Lys - Gln - Met - Ala - Val - Lys - Lys - Tyr - Leu - Ala - Ala - Val - Leu - Gly - Lys - Arg - Tyr - Lys - Gln - Arg - Val - Lys - Asn - Lys-NH₂


PTH (parathormone) (84 aa) :
Ser - Val - Ser - Glu - Ile - Gln - Leu - Met - His - Asn - Leu - Gly - Lys - His - Leu - Asn - Ser - Met - Glu - Arg - Val - Glu - Trp - Leu - Arg - Lys - Lys - Leu - Gln - Asp - Val - His - Asn - Phe - Val - Ala - Leu - Gly - Ala - Pro - Leu - Ala - Pro - Arg - Asp - Ala - Gly - Ser - Gln - Arg - Pro - Arg - Lys - Lys - Glu - Asp - Asn - Val - Leu - Val - Glu - Ser - His - Glu - Lys - Ser - Leu - Gly - Glu - Ala - Asp - Lys - Ala - Asp - Val - Asn - Val - Leu - Thr - Lys - Ala - Lys - Ser - Gln


- PTH-RP (Parathormone-Related Peptide) (141 aa)


Polypeptide pancréatique (PP) (36 aa) :
Ala - Pro - Leu - Glu - Pro - Val - Tyr - Pro - Gly - Asp - Asn - Ala - Thr - Pro - Glu - Gln - Met - Ala - Gln - Tyr - Ala - Ala - Asp - Leu - Arg - Arg - Tyr - Ile - Asn - Met - Leu - Thr - Arg - Pro - Arg - Tyr-NH₂


Icosapeptide pancréatique (20 aa) :
His - Lys - Glu - Asp - Thr - Leu - Ala - Phe - Ser - Glu - Trp - Gly - Ser - Pro - His - Ala - Ala - Val - Pro - Arg


Prolactin-releasing peptide (PRL-releasing peptide - PrRP) :
Ser - Arg - Thr - His - Arg - His - Ser - Met - Glu - Ile - Arg - Thr - Pro - Asp - Ile - Asn - Pro - Ala - Trp - Tyr - Ala - Ser - Arg - Gly - Ile - Arg - Pro - Val - Gly - Arg - Phe-NH₂


Sécrétine (27 aa) :
His - Ser - Asp - Gly - Thr - Phe - Thr - Ser - Glu - Leu - Ser - Arg - Leu - Arg - Glu - Gly - Ala - Arg - Leu - Gln - Arg - Leu - Leu - Gln - Gly - Leu - Val-NH₂


Somatostatine-14 (14 aa) :
Arg - Pro - Lys - Pro - Gln - Gln - Phe - Phe - Gly - Leu - Met-NH₂


Somatostatine-28 (28 aa) :
Ser - Ala - Asn - Ser - Asn - Pro - Ala - Met - Ala - Pro - Arg - Glu - Arg - Lys - Arg - Pro - Lys - Pro - Gln - Gln - Phe - Phe - Gly - Leu - Met-NH₂


Substance K (neurokinine A, neuromédine L) (11 aa) :
His - Lys - Thr - Asp - Ser - Phe - Val - Gly - Leu - Met-NH₂


Substance P (11 aa) :
Arg- Pro- Lys- Pro- Gln- Gln- Phe- Phe- Gly- Leu- Met-NH₂


- SP / Neuropeptide K (36 aa) / neuropeptide-g (21 aa)


Thyrotropin-Releasing Hormone (TRH) (3 aa) :
pyroGlu - His - Pro-NH₂


- TRH / TRH-potentiating peptide (10 aa)


Urocortine (40 aa) :
Asp - Asn - Pro - Ser - Leu - Ser - Ile - Asp - Leu - Thr - Phe - His - Leu - Leu - Arg - Thr - Leu - Leu - Glu - Leu - Ala - Arg - Thr - Gln - Ser - Gln - Arg - Glu - Arg - Ala - Glu - Gln - Asn - Arg - Ile - Ile - Phe - Asp - Ser - Val-NH₂


Urotensine II (11 aa) (pont disulfure : Cys⁵ - Cys¹⁰) :
Glu - Thr - Pro - Asp - Cys - Phe - Trp - Lys - Tyr - Cys - Val


Vasopressine (9 aa) (pont disulfure : Cys¹ - Cys⁶) :
Cys - Tyr - Phe - Gln - Asn - Cys - Pro - Arg - Gly-NH₂


VIP (Vasoactive Intestinal Peptide) (28 aa) :
His - Ser - Asp - Ala - Val - Phe - Thr - Asp - Asn - Tyr - Thr - Arg - Leu - Arg - Lys - Gln - Met - Ala - Val - Lys - Lys - Tyr - Leu - Asn - Ser - Ile - Leu - Asn-NH₂


Peptide His-Met 27 (PHM27) :
His - Ala - Asp - Gly - Val - Phe - Thr - Ser - Asp - Phe - Ser - Lys - Leu - Leu - Gly - Gln - Leu - Ser - Ala - Lys - Lys - Tyr - Leu - Glu - Ser - Leu - Met-NH₂