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La famille hétérogène des récepteurs de la neurotensine :
Pharmacologie, signalisation et traffic intracellulaire :


Auteur : Dr. Stéphane MARTIN - IPMC, CNRS UMR 6097, Sophia Antipolis, France.

Adresse actuelle : MRC Centre for Synaptic Plasticity - Department of Anatomy - Bristol University - UK.


Première partie - la neurotensine :

Références bibliographiques :


Bean, A.J., Dagerlind, A., Hokfelt, T. and Dobner, P.R. (1992) Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. Neuroscience, 50, 259-268.

Bepler, G., Rotsch, M., Jaques, G., Haeder, M., Heymanns, J., Hartogh, G., Kiefer, P. and Havemann, K. (1988) Peptides and growth factors in small cell lung cancer: production, binding sites, and growth effects. J Cancer Res Clin Oncol, 114, 235-244.

Bérod, A. and Rostène, W. (2002) Neurotensin: an endogenous psychostimulant? Curr Opin Pharmacol, 2, 93-98.

Binder, E.B., Kinkead, B., Owens, M.J., Kilts, C.D. and Nemeroff, C.B. (2001) Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating. J Neurosci, 21, 601-608.

Carraway, R. and Leeman, S.E. (1973) The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem, 248, 6854-6861.

Carraway, R. and Leeman, S.E. (1975) The amino acid sequence of a hypothalamic peptide, neurotensin. J Biol Chem, 250, 1907-1911.

Carraway, R.E., Mitra, S.P. and Paradise, C. (1991) Characterization of large neuromedin-N using antisera towards regions of the neurotensin/neuromedin-N precursor. Peptides, 12, 601-607.

Coquerel, A., Dubuc, I., Menard, J.F., Kitabgi, P. and Costentin, J. (1986) Naloxone-insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan. Brain Res, 398, 386-389.

De la Fuente, M., Garrido, J.J., Arahuetes, R.M. and Hernanz, A. (1993) Stimulation of phagocytic function in mouse macrophages by neurotensin and neuromedin N. J Neuroimmunol, 42, 97-104.

Dobner, P.R., Barber, D.L., Villa-Komaroff, L. and McKiernan, C. (1987) Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor. Proc Natl Acad Sci U S A, 84, 3516-3520.

Dobner, P.R., Fadel, J., Deitemeyer, N., Carraway, R.E. and Deutch, A.Y. (2001) Neurotensin-deficient mice show altered responses to antipsychotic drugs. Proc Natl Acad Sci U S A, 98, 8048-8053.

Evers, B.M., Izukura, M., Chung, D.H., Parekh, D., Yoshinaga, K., Greeley, G.H., Jr., Uchida, T., Townsend, C.M., Jr. and Thompson, J.C. (1992) Neurotensin stimulates growth of colonic mucosa in young and aged rats. Gastroenterology, 103, 86-91.

Frye, G.D., Luttinger, D., Nemeroff, C.B., Vogel, R.A., Prange, A.J., Jr. and Breese, G.R. (1981) Modification of the actions of ethanol by centrally active peptides. Peptides, 2, 99-106.

Garrido, J.J., Arahuetes, R.M., Hernanz, A. and De la Fuente, M. (1992) Modulation by neurotensin and neuromedin N of adherence and chemotaxis capacity of murine lymphocytes. Regul Pept, 41, 27-37.

Goldman, R., Bar-Shavit, Z. and Romeo, D. (1983) Neurotensin modulates human neutrophil locomotion and phagocytic capability. FEBS Lett, 159, 63-67.

Gully, D., Canton, M., Jeanjean, F., Molimard, J.C., Poncelet, M. and al. (1993) Biochemical and pharmacological profile of a potent and selective nonpeptide antagoniste receptor. Proc Natl Acad Sci U S A, 90, 65-69.

Hellstrom, P.M., Nylander, G. and Rosell, S. (1982) Effects of neurotensin on the transit of gastrointestinal contents in the rat. Acta Physiol Scand, 115, 239-243.

Helmstaedter, V., Taugner, C., Feurle, G.E. and Forssmann, W.G. (1977) Localization of neurotensin-immunoreactive cells in the small intestine of man and various mammals. Histochemistry, 53, 35-41.

Kinkead, B. and Nemeroff, C.B. (2002) Neurotensin: an endogenous antipsychotic? Curr Opin Pharmacol, 2, 99-103.

Kislauskis, E., Bullock, B., McNeil, S. and Dobner, P.R. (1988) The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences. J Biol Chem, 263, 4963-4968.

Kitabgi, P., Checler, F., Mazella, J. and Vincent, J.P. (1985) Pharmacology and biochemistry of neurotensin receptors. Rev Clin Basic Pharm, 5, 397-486.

Luttinger, D., Frye, G.D. and Bissette, G. (1982) Effects of neurotensin on the actions of barbiturates and ethanol. Ann N Y Acad Sci, 400, 259-267.

Maoret, J.J., Pospai, D., Rouyer-Fessard, C., Couvineau, A., Laboisse, C., Voisin, T. and Laburthe, M. (1994) Neurotensin receptor and its mRNA are expressed in many human colon cancer cell lines but not in normal colonic epithelium: binding studies and RT-PCR experiments. Biochem Biophys Res Commun, 203, 465-471.

McCann, S.M. and Vijayan, E. (1992) Control of anterior pituitary hormone secretion by neurotensin. Ann N Y Acad Sci, 668, 287-297.

Motta, M. and Martini, L. (1981) Neurotensin inhibits LH release. Proc Soc Exp Biol Med, 168, 62-64.

Nemeroff, C.B., Osbahr, A.J.d., Manberg, P.J., Ervin, G.N. and Prange, A.J., Jr. (1979) Alterations in nociception and body temperature after intracisternal administration of neurotensin, beta-endorphin, other endogenous peptides, and morphine. Proc Natl Acad Sci U S A, 76, 5368-5371.

Orci, L., Baetens, O., Rufener, C., Brown, M., Vale, W. and Guillemin, R. (1976) Evidence for immunoreactive neurotensin in dog intestinal mucosa. Life Sci, 19, 559-561.

Osbahr, A.J.d., Nemeroff, C.B., Luttinger, D., Mason, G.A. and Prange, A.J., Jr. (1981) Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormone. J Pharmacol Exp Ther, 217, 645-651.

Reinecke, M. (1985) Neurotensin. Immunohistochemical localization in central and peripheral nervous system and in endocrine cells and its functional role as neurotransmitter and endocrine hormone. Prog Histochem Cytochem, 16, 1-172.

Rostène, W.H. and Alexander, M.J. (1997) Neurotensin and neuroendocrine regulation. Front Neuroendocrinol, 18, 115-173.

Rovère, C., Barbero, P. and Kitabgi, P. (1996) Evidence that PC2 is the endogenous pro-neurotensin convertase in rMTC 6-23 cells and that PC1- and PC2-transfected PC12 cells differentially process pro-neurotensin. J Biol Chem, 271, 11368-11375.

Seethalakshmi, L., Mitra, S.P., Dobner, P.R., Menon, M. and Carraway, R.E. (1997) Neurotensin receptor expression in prostate cancer cell line and growth effect of NT at physiological concentrations. Prostate, 31, 183-192.

Tanganelli, S., O'Connor, W.T., Ferraro, L., Bianchi, C., Beani, L., Ungerstedt, U. and Fuxe, K. (1994) Facilitation of GABA release by neurotensin is associated with a reduction of dopamine release in rat nucleus accumbens. Neuroscience, 60, 649-657.

Thor, K. and Rokaeus, A. (1983) Studies on the mechanisms by which (Gln4)-neurotensin reduces lower esophageal sphincter (LES) pressure in man. Acta Physiol Scand, 118, 373-377.

Uhl, G.R., Kuhar, M.J. and Snyder, S.H. (1977) Neurotensin: immunohistochemical localization in rat central nervous system. Proc Natl Acad Sci U S A, 74, 4059-4063.

van Wimersma Greidanus, T.B., van Praag, M.C., Kalmann, R., Rinkel, G.J., Croiset, G., Hoeke, E.C., van Egmond, M.A. and Fekete, M. (1982) Behavioral effects of neurotensin. Ann N Y Acad Sci, 400, 319-329.

Wagstaff, J.D., Bush, L.G., Gibb, J.W. and Hanson, G.R. (1994) Endogenous neurotensin antagonizes methamphetamine-enhanced dopaminergic activity. Brain Res, 665, 237-244.

Watt, C.B., Li, H.B. and Lam, D.M. (1985) The presence of three neuroactive peptides in putative glycinergic amacrine cells of an avian retina. Brain Res, 348, 187-191.

Wood, J.G., Hoang, H.D., Bussjaeger, L.J. and Solomon, T.E. (1988) Effect of neurotensin on pancreatic and gastric secretion and growth in rats. Pancreas, 3, 332-339.

Zsürger, N. (2001) Les récepteurs de la neurotensine chez les mammifères : caractérisation, purification, ontogenèse et vieillissement. Thèse, Nice-Sophia Antipolis.



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